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Spinal Cord

Caused by trauma to the spine, spinal cord injuries are known to affect motor skills and can potentially lead to total loss function in some parts of the body. Research suggests cannabis can help patients treat the pain and muscle spasms that are often symptomatic of a spinal cord injury, with investigators from the Oxford Centre for Enablement, see below, noting that “Cannabis medicinal extracts can improve neurogenic symptoms unresponsive to standard treatments”.

A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms.

OBJECTIVES:

To determine whether plant-derived cannabis medicinal extracts (CME) can alleviate neurogenic symptoms unresponsive to standard treatment, and to quantify adverse effects.

DESIGN:

A consecutive series of double-blind, randomized, placebo-controlled single-patient cross-over trials with two-week treatment periods.

SETTING:

Patients attended as outpatients, but took the CME at home.

SUBJECTS:

Twenty-four patients with multiple sclerosis, spinal cord injury, brachial plexus damage, and limb amputation due to neurofibromatosis.

INTERVENTION:

Whole-plant extracts of delta-9-tetrahydrocannabinol (THC), cannabidiol (CBD), 1:1 CBD:THC, or matched placebo were self-administered by sublingual spray at doses determined by titration against symptom relief or unwanted effects within the range of 2.5-120 mg/24 hours. Measures used: Patients recorded symptom, well-being and intoxication scores on a daily basis using visual analogue scales. At the end of each two-week period an observer rated severity and frequency of symptoms on numerical rating scales, administered standard measures of disability (Barthel Index), mood and cognition, and recorded adverse events.

RESULTS:

Pain relief associated with both THC and CBD was significantly superior to placebo. Impaired bladder control, muscle spasms and spasticity were improved by CME in some patients with these symptoms. Three patients had transient hypotension and intoxication with rapid initial dosing of THC-containing CME.

CONCLUSIONS:

Cannabis medicinal extracts can improve neurogenic symptoms unresponsive to standard treatments. Unwanted effects are predictable and generally well tolerated. Larger scale studies are warranted to confirm these findings.

Spinal Cord Disease

The term ‘spinal cord disease’ refers to any spinal cord issues that develop for reasons other than trauma. Multiple sclerosis, spina bifida, syringomyelia and spinal stenosis can all be considered examples of spinal cord disease. Patients living with a spinal cord disease may find therapeutic value in using cannabis based medicine, thanks to cannabis’ ability to alleviate spasticity and pain – two of the most common symptoms associated with spinal cord disease.